Arnaud Zenerino has been awarded by the C’Nano PACA for his PhD thesis. This study, which is a part of the "Bioactive surfaces" project and supervised by Frédéric Guittard, dealt with the development polymerized nanoparticles with adsorption and/or decontamination properties.
The Thesis Prize award ceremony will take place during the workshop "Journées Scientifiques du C’Nano PACA".
Abstract of the thesis
Chemicals warfare or civilian agents are organophosphorous compounds with a high toxicity that can provoke, for example, skins burns, suffocation, and even the human death by targeting human’s nervous system. In order to limit this contamination, new cosmetics products to protect the skin against chemical agents are necessary. The aim of this work was to synthesize a nanocomposite containing inorganic nanoparticles, with adsorption and/or decontamination properties as a function of the nanoparticles used, grafted to a rheological modifier such as hydrocarbon or fluorocarbon ASE or HASE polymers to obtain efficient barrier properties against these chemical agents.
First, nanoparticles were functionalized to react with acid carboxylic groups of ASE and HASE copolymers. Many copolymers were synthesized in order to determine the best viscosity and oleophobic properties for our application. Thereafter the grafting of polymer/nanoparticles puts in evidence the importance of free acid carboxylic quantity and fluorocarbon length for the nanoparticles dispersion in solution and on the coating. Finally, toxicological environmental tests with microorganisms showed that polymer/nanoparticles nanocomposite has no toxicity. Furthermore efficacy as barrier agents against VX and paraoxon organophosphorus compounds was evaluated by in vitro tests.
In conclusion, it was noticed that the barrier effect of the nanoparticles grafted polymers was increased compared to the polymer alone and also to a commercial topical skin protectant. These results confirm that the grafting of nanoparticles to the polymers is a suitable approach in the synthesis of new topical skin protectant.
A. Zenerino, S. Amigoni, E. Taffin de Givenchy, D. Josse, F. Guittard, Nanoparticules polymérisées en réseau actif ou bioactif, topiques protecteurs, leurs procédés de préparation et leurs utilisations, FR Patent, N° d’enregistrement FR13/00396.
A. Zenerino, S. Amigoni, E. Taffin de Givenchy, D. Josse, T. Devers, F. Guittard, Nanoparticules de cérine polymérisées en réseau actif ou bioactif, topiques protecteurs, leurs procédés de préparation et leurs utilisations, FR Patent, N° d’enregistrement FR13/01712.
L. Clément, A. Zenerino, C. Hurel, S. Amigoni, E. Taffin de Givenchy, F. Guittard, N. Marmier, Toxicity assessment of silica nanoparticles, functionalised silica nanoparticles, and HASE-grafted silica nanoparticles, Science of the Total Environment, 2013, 450-451, 120-128.
A. Zenerino, S. Amigoni, E. Taffin de Givenchy, D. Josse, F. Guittard, Homogeneous dispersion of SiO2 nanoparticles in an hydrosoluble polymeric network, Reactive and Functional Polymers, 2013, 73, 1065-1071.
A. Zenerino, S. Amigoni, E. Taffin de Givenchy, D. Josse, F. Guittard, New fluorinated hybrid organic/inorganic water soluble polymeric network, Polymer, 2013, in press.
Fluides & Matériaux Complexes, Doctorants/Post-doctorants
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