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Nanoparticules en réseau pour la protection cutanée

Thèse Cécile Bignon

à 11h en salle C. Brot

Chemical warfare agents and pesticides are toxic molecules causing temporary incapacitation or permanent harms leading to the death of people. One of the major routes of contamination is the percutaneous penetration. Skin protection is important to prevent these dangers. The aim of this thesis is to develop new active topical skin protectants based on nanoparticular networks containing fluorinated HASE polymers grafting with silica, cerium or titanium nanoparticles. First, polymers were synthesized in larger quantity and their wettability properties improved. Toxicological studies have showed that these compounds are non-irritant and non-toxic for the environment. The formulation of these polymers has led to the elaboration of two new barrier creams against paraoxon penetration whose efficiency is dependent on the presence of nanoparticles. Therefore, the grafting of nanoparticles to fluorinated HASE polymer and their formulation have enabled the development of new active topical skin protectant. Efficiency evaluation was done using artificial membranes and was confirmed on ex vivo human skin. The limited availability of human skin explants has motivated the development of a new efficiency model using reconstructed human epidermis.