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Mechanical self organized processes involved in vascular morphogenesis

Annemiek JM Cornelissen

Mercredi 20 octobre 2010

à 11h en salle C. Brot

There is emerging evidence that the shape and the organization of living organisms is not entirely included in the genetic code and that the role of mechanics is maybe important. We aim to develop a basic understanding on how stress tensors in the growing tissue are involved in several basic mechanisms for vascular morphogenesis. Here I will focus on the role of stress gradients in the growing tissue on vessel guidance. Therefore we observed in vivo vascular development in the chicken embryo yolk-sac and in a far simpler biological model for vascular morphogenesis, the jellyfish (Aurelia Aurita). These observations are correlated with in vivo measurements of mechanical properties of tissue using microrheology and scanning air puff tonometry (Fleury et al Physical Review e 2010 ;81(2)). Applying simple mathematical models, tissue deformation is related to vascular patterning, showing that in-tissue stress gradients are closely associated with the paths taken by the newly generated vessels.

ps : invitée par J. Rajchenbach